Synthesis, docking study and anticancer activity of coumarin substituted derivatives of benzothiazole
نویسندگان
چکیده
During the last 2 decades, the study of the biological activities of Coumarin derivatives has been the aim of many researchers. Based on these findings, a series of Coumarin substituted benzothiazoles were synthesized by refluxing Coumarin-4-carboxaldehyde and oaminothiophenol in acetic acid. Compounds were characterized by IR, 1H NMR and mass spectroscopy. All the compounds were tested for their anticancer activity against MCF-7 breast cancer cell line with MTT assay. Most of the compounds showed moderate to good anti-breast cancer activity. Docking studies of the synthesized compounds was done with the help of VLife MDS 3.0 software using GRIP batch docking method to study their observed activity.
منابع مشابه
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